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Significant association of MCP1 rs1024611 and CCR2 rs1799864 polymorphisms with colorectal cancer and liver metastases susceptibility and aggressiveness: A case-control study

Rahma Boughriba,Ghada Sahraoui,Ines Chaar,Marwa Weslati,Khouloud Ayed,Donia Ounissi, Mariem Hazgui,Saadia Bouraoui,Asma Gati

Cytokine（2023）

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Abstract
•MCP1 rs1024611 and CCR2 rs1779864 were associated with increased CRC and CRLM risk, elevated CEA serum levels, and poor prognostic features.•Poor survival rate was noted among MCP1 rs1024611 mutated genotype carriers.•Neoadjuvant treatment based on radio- or radiochemotherapy showed survival rate improvement among MCP1 and CCR2 wild-type genotypes carriers.•FOLFIRI chemotherapy was associated with decreased CRC survival rate among MCP1 and CCR2 mutated genotypes carriers.
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Key words
MCP1,CCR2,Polymorphism,Colorectal cancer,Colorectal liver metastasis,Overall survival,Treatment approaches,Chemotherapy
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