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Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries

Marta Larrayoz,Jose A. Martinez-Climent

NATURE MEDICINE（2023）

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Abstract
To meet a current unmet medical need, we generated 15 genetically engineered mouse models that accurately reflect the key pathogenetic aspects of human multiple myeloma. By coupling mechanistic investigations and pre-clinical immunotherapy testing, these pre-clinical platforms provide knowledge that will aid the optimization of future immunotherapy clinical trial design.
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