Bromelain and its anti-inflammatory therapeutic application in humans: a scope review

Introduction: Bromelain is a mixture of cysteine pro-teases found in tissue obtained from pineapple, Ananas co-mosus Merr, belonging to the bromeliad family. In-vivo and in -vitro studies have shown anti-inflammatory therapeutic efficacy through the elimination of molecules from the cell surface, a decrease in plasmakinin levels, a prostaglandin in-hibitor, pro-inflammatory cytokines, in addition to increasing tissue permeability through fibrinolysis and promoting the re -absorption of edema fluid in the bloodstream.Objective: This review aims to analyze the available evi-dence on the application and anti-inflammatory therapeutic dosage in humans of bromelain.Material and methods: Articles with a period from 2010 to 2023 on bromelain and its anti-inflammatory activity in humans were collected, based on the PRISMA criteria. The bibliographic search was carried out in seven electronic databases: PubMed, Scopus, Springer Link, Ovid, Redalyc, Scielo and Wiley.Results: Six of the twelve articles selected to carry out the work show the potential of bromelain as a possible alternative to anti-inflammatory treatment. These studies have reported significant differences reporting therapeutic effects between study groups with administration from 160 mg/d, 500mg/d, 1000 mg/d, 1000 FIP and 3000 FIP respectively with different dosing schedules.Discussion: One of the main disadvantages observed in the reviewed articles was that the methodology is very varied, which makes it difficult to compare them. At the moment, in-formation on the use of bromelain in inflammation is scarce in its application in humans, compared to other nutraceuticals.Conclusion: The importance of the usefulness of brome -lain as an anti-inflammatory agent lies in the treatment of in-flammation. It is necessary to increase double-blind studies with specific doses in humans that evaluate inflammatory markers in different pathological processes.