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Effects of a neurokinin-1 receptor antagonist in the acute phase after thoracic spinal cord injury in a rat model.

Guoli Zheng,Anna-Kathrin Harms,Mohamed Tail,Hao Zhang,Alan Nimmo,Thomas Skutella,Karl Kiening,Andreas Unterberg,Klaus Zweckberger,Alexander Younsi

Frontiers in molecular neuroscience（2023）

Cited 2|Views5
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Abstract
Intrathecal administration of NRA might reinforce the integrity of the BSCB in the acute phase after SCI, potentially attenuating aspects of neurogenic inflammation, reducing edema formation, and improving functional recovery.
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Key words
spinal cord injury,animal model,neurokinin-1 (NK1) antagonist,blood spinal cord barrier,inflammation,behavioral assessment
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