Hyperhomocysteinemia Is Associated With Lipid Profiles and Lipid Ratio in Patients With Coronary Artery Disease

Abstract Objective: This study aimed to investigate the correlation of Hyperhomocysteinemia (HHcy) or serum homocysteine (Hcy) levels with lipid levels and lipid ratios in individuals with coronary artery disease(CAD).Methods: A total of 1646 subjects with suspected CAD were divided into CAD or control groups. Serum Hcy, total cholesterol(TC), triglycerides(TGs), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), apolipoprotein(Apo)AI and ApoB concentrations were detected.Results: Serum TC, LDL-C and ApoB in control subjects with HHcy were lower than those in individuals with normal Hcy, and serum HDL-C and ApoAI in CAD subjects with HHcy were lower than those in individuals with normal Hcy(P < 0.05). The correlation analysis showed that serum TGs, LDL-C, ApoAI and HDL-C were correlated with Hcy(P <0.05). There are different HHcy trends affecting the ratios of TC/HDL-C and LDL/HDL-C between the CAD and controls(Pinteraction for TC/HDL-C=0.025; Pinteraction for LDL/HDL-C=0.033). CAD patients with HHcy had a higher ratio of TC/HDL-C(P=0.022) and LDL/HDL-C(P=0.045) than those with normal Hcy, but in the controls, the subjects with HHcy exhibited a trend toward a decreased ratio of TC/HDL-C(P=0.481) and LDL/HDL-C(P=0.303).Conclusion: HHcy was related to the atherogenic lipid profile in patients with CAD. The lipid ratio is more suitable for assessing the effect of HHcy on CAD.