Reduced amplification efficiency of the RNA-dependent-RNA-polymerase (RdRp) target enables tracking of the Delta SARS-CoV-2 variant using routine diagnostic tests

Ziyaad Valley-Omar,Gert Marais,Arash Iranzadeh,Michelle Naidoo,Stephen Korsman, Tongai Maponga,Hannah Hussey,Mary-Ann Davies,Andrew Boulle,Deelan Doolabh, Mariska Laubscher, JD Deetlefs,Jean Maritz,Lesley Scott,Nokukhanya Msomi,Houriiyah Tegally,Tulio de Oliveira,Jinal Bhiman,Carolyn Williamson,Wolfgang Preiser,Diana Hardie,Nei-yuan Hsiao

medRxiv (Cold Spring Harbor Laboratory)（2021）

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摘要

AbstractRoutine SARS-CoV-2 surveillance in the Western Cape region of South Africa (January-August 2021) found a reduced PCR amplification efficiency of the RdRp gene target of the Seegene, Allplex 2019-nCoV diagnostic assay when detecting the Delta variant. We propose that this can be used as a surrogate for variant detection.

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关键词

rna-dependent-rna-polymerase,sars-cov

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