The In-Hospital Prognostic Value of High Sensitivity C-Reactive Protein in STEMI Patients Treated by Thrombolysis Versus Primary Percutaneous Coronary Intervention

Introduction: Coronary artery disease (CAD) is considered a major causative agent of mortality and morbidity.Many reports recommended the use of C-reactive protein (CRP) as an inflammatory marker for its high sensitivity that could help in prevention of CAD.Objective: This work aimed to clarify the in-hospital prognostic value of high-sensitivity CRP (hs-CRP) in ST-elevation myocardial infarction (STEMI) cases who are treated by thrombolysis vs. primary percutaneous coronary intervention (PCI) and comparing the outcome of the treatment between the two groups.Patients and methods: 48 STEMI cases were divided into two groups in this cross-section study: Patients in group A had Primary PCI, whereas those in group B received thrombolysis treatment.Patients were evaluated by history, examinations, investigations and coronary angiography.Results: Most of patients had grade II mitral regurge (68.8%) with statistical insignificant differences between the study groups.Most of patients had wall motion abnormalities in anterior septum (43.8%) with statistical insignificant difference between groups.In this study, 41.7% of patients had positive troponin with statistical insignificant difference between groups.According to distribution of patients as regards outcomes, died patient and patients with heart failure had significantly higher median of first-and second-hour CRP than patients without adverse events Conclusion: Impaired reperfusion was correlated with higher hs-CRP compared to optimal reperfusion.This study was conducted on CRP so further investigation with larger population size are necessary especially for inflammatory cascade.