Ameliorative Effect of Nanocurcumin and/or Saccharomyces Cell Wall Against Aflatoxicosis in Broilers

Abstract Background The adverse effect of aflatoxin in broilers well known. However, dietary supplementation of nanocurcumin and/or Saccharomyces cell wall may decrease the bad effect of aflatoxin B1 because of their bio-adsorbing feature of the functional ingredients in Yeast Cell Wall and the detoxification effect of curcumin nanoparticles. The goal of this study was to see how nanocurcumin and/or Saccharomyces cell wall supplementation and/or aflatoxin affected broiler development, blood and serum parameters, carcass trait, histology, immune histochemistry, liver gene expression, and aflatoxin residue in the liver and muscle tissue of broilers. Broiler chicks with one day old were distributed into five groups according to nanocurcumin and/or saccharomyces cell wall with aflatoxin supplementation. The G1 group was given a formulated diet without any supplements. The G2 group was supplemented with aflatoxin (0.25 mg/kg diet) in the formulated diet. The G3 group was supplemented with aflatoxin (0.25 mg/kg diet) and Saccharomyces cell wall (1Kg/Ton diet) in the formulated diet. The G4 group was supplemented with aflatoxin (0.25 mg/kg diet) and nanocurcumin (400 mg/kg) in the formulated diet. The G5 group was supplemented with aflatoxin (0.25 mg/kg diet) and Saccharomyces cell wall (1Kg/Ton diet) with nanocurcumin (200 mg/kg) in the formulated diet. Results Aflatoxin supplementation had a detrimental impact on the growth performance, blood and serum parameters, carcass trait, and aflatoxin residue in the liver and muscle tissue of broilers, according to the results of this study. In addition, aflatoxin supplementation led to a liver injury that was indicated by serum biochemistry and pathological lesions in the liver tissue. Moreover, the intestinal villi, length, and width were affected. The expression of some genes in the liver tissue was affected. Conclusion Saccharomyces cell wall alone or with nanocurcumin attenuated these negative effects and anomalies, and improving all of the above-mentioned metrics.