Natural product inspired chiral ligand design: Aloperine induced asymmetric hydroarylation of ketimines under Pd catalysed conditions

A naturally occurring alkaloid aloperine was utilized as a core chiral skeleton for the development of new ligands. Using these chiral 1,3-diamine ligands, a Pd catalysed asymmetric hydroarylation of ketimines was reported. A range of chiral sulfonyl amides were prepared in high yields and enantioselectivties. The stereoselectivity and structure relationships of aloperine has been studied by the introduction of various subsitituents. These discoveries would provide a new future development for natural product inspired chiral ligand design and developments.