The Association Of Hypertriglyceridemic Waist Phenotype With Uric Acid: A Cross-Sectional Study In A Chinese Population

Abstract Background: The aim of this study was to research the association between the hypertriglyceridemic-waist (HTGW) phenotype and uric acid in a large general population.Methods: A total of 9015 participants from the cross-sectional study were enrolled. The hypertriglyceridemic-waist (HTGW) phenotype was defined as elevated waist circumference (WC) and elevated triglyceride (TG) concentration. Linear and Multiple logistic regression models were used for measuring the association between HTGW phenotype and uric acid.Results: Total prevalence of hyperuricemia was 17.3% and the prevalence of hyperuricemia were 31.6 % in HTGW phenotype. Subjects with HTGW phenotype were more likely to have hyperuricemia (OR=1.47, 95%CI: 1.11–1.95, P=0.007) compared with subjects with NTNW group. Furthermore, the stratified analysis showed that the strongest positive association of HTGW phenotype with hyperuricemia was found in the subgroup of presence of CKD. The associations were all fully adjusted for confounding factors.Conclusion: Our study suggested a positive association between the HTGW phenotype and hyperuricemia in Chinese people. Further prospective studies are warranted to confirm our findings and to investigate the underlying biological mechanisms.