Does the Rubella Immunoglobulin G affect the severity of COVID- 19? Rubella Immunoglobulin G and COVID- 19

Abstract Objective &Aim: The coronavirus disease, so far (COVID-19) has brought about millions of infections and fatalities throughout the world. Our aim was to determine whether rubella IGG titers are inversely correlated with severity COVID-19 patients.Materials & Methods: This study was conducted among COVID-19 confirmed patients over 18 years of age. The disease severity levels were categorized by WHO interim guidance. The rubella-specific IgG antibody-titer spectrum was measured (within first 48 hours of hospitalization) by enzyme-linked immunosorbent assay (ELISA). Result: in a study of 46 inpatients with varying COVID-19 disease severity (mild, moderate, severe, and critical), we observed a negative correlation between rubella IgG antibody titers and COVID‐19 severity (P-Value=0.03), There was an interaction between COVID-19 vaccination history and rubella IGG on severity COVID-19 (P-Value=0.0015). There was an interaction between age group under 44 years (including national measles- rubella (MR) vaccination in Iran) and rubella IGG titers on severity COVID-19 too (p-value=0.014).Conclusion: In conclusion, MR vaccination seems to have a positive effect in reducing the severity of the disease, emphasizing that, the important and separate effect of the IGG rubella (due to natural or extrinsic immunity) titers is determining.