A Ruthenium Arene Complex with Central, Planar and Axial Chirality

The preparations of organometallic molecules have provided new philosophy in molecular science. The synthesis of these molecules featured in easy construction, modification and broad chemical space coverage comparing to the access of carbon centered compounds. The stereochemistry of these molecules have long been the great challenge due to the large atom radius therefore more outer sphere electrons give rise to more valency. Transition metals centered molecules in particular become the new summit for the studies of these molecules with respect to the design, synthesis and analysis. We herein report the construction and resolution of a number of ruthenium piano-stool shaped complexes, and stability studies of these complexes. Furthermore, 5 conformational isomers were detected in complex 16, the rotate barrier between the two conformations was around 3 kcal/mol. These results have provided new evidences for the design of molecules with specific fine stereochemical information for potential applications in medicinal and material chemistry.