The effect of omeprazole on urinary excretion of magnesium in children with peptic diseases

Abstract Purpose: This study aimed to assess the effect of omeprazole on urinary excretion of magnesium in children receiving omeprazole for treatment of peptic disease. What is the effect of omeprazole on urinary fractional excretion of magnesium? Methods: This single-armed clinical trial study was conducted on 44 children with a diagnosis of acid peptic disease who was treated with omeprazole (1-2 mg/kg/day) for 3 months in Gastroenterology clinics of Imam Hossein hospital, 2021, Isfahan, Iran. Before and after the intervention, serum levels of magnesium and creatinine and urine magnesium and creatinine levels were measured by Pars Azmoon Kit based on the guideline of the kit. Then fractional excretion of magnesium (Mg) was calculated based on the formula. Results: The mean urinary magnesium levels before and after intervention were 4.96±2.48 and 1.46±0.63, respectively (P<0.001). A significant decrease in serum Mg level was also observed after treatment versus before treatment (1.37±0.03 vs. 1.9±0.2, P<0.01). The mean fractional Mg excretion before and after therapy were 5.2±1.2 and 1.7±0.63, respectively (P<0.01). Serum creatinine level before and after therapy was 0.62±0.19 and 0.67±0.13, respectively (p=0.053). Urinary creatinine level was increased after intervention by 20.80±18.77 (p<0.001). Conclusion: The cause of hypomagnesemia is not increased urinary loss of magnesium, conversely, the kidney effort to compensate for the drop in blood magnesium following omeprazole treatment, by reducing urinary excretion of it and saving magnesium ions in the body.