Sleep Duration and Risk of Atherosclerosis --A Mendelian Randomization Study

Abstract Background:Observational studies have suggested associations between sleep duration and atherosclerosis(AS).However,it’s role as a risk factor or as a subeffect because of atherosclerosis is uncertain.Methods:We performed a literature search of genome-wide studies that evaluate sleep duration.We used a two -sample Mendelian randomization approach to evaluate the causality of sleep duration on atherosclerosis risk,using 2 cohorts:MRC-IEU (n=460,099)and UK Biobank(n=361,194).The two-sample MR study was conducted to estimate causal relationship between sleep duration and AS,with the inverse-variance weighted (IVW)method,Robust adjusted profile score (RAPS),simple-and weighted-median method.Moreover,MR-Egger regression,RadialMR,MR-PRESSO and leave-one-out analysis were performed to evaluate the potential pleiotropy effect.Results:Genome-wide association studies of sleep duration were evaluated.No associations were found in relation to atherosclerosis(odds ratio=0.90[95% CI,0.98-1.00];p-value=1.86×10−1).MR-Egger,MR-PRESSO,and leave-one-out analysis did not indicate horizontal pleiotropy.Conclusion:Our MR study suggested that genetically predicted sleep duration was not causally associated with AS among the European populations.