The Role of Prognostic Nutritional Index and Systemic Immune-Inflammation Index in Determining Ulcerative Colitis Severity

Aim: Ulcerative colitis (UC) is a chronic, idiopathic, relapsing inflammatory disease of the gastrointestinal tract.In recent years, biochemical parameters have been widely used to determine the disease activity of UC.The present study aimed to determine the relationship between the prognostic nutritional index (PNI), systemic immune-inflammation index (SII), and disease activity.Material and Method: All adult patients followed in the IBD unit of the Ankara City Hospital Gastroenterology Department between March 1st, 2019, and March 31st, 2021, were included in this retrospective study.We analyzed the relationship between the SII, PNI, and the endoscopic severity of UC.In addition, PNI and SII were compared between the active and remission group.Disease activity was described by the Rachmilewitz endoscopic activity index (EAI). Results:The study group consisted of 402 patients.One hundred sixty-five of these patients were in the endoscopic remission group, and 237 were in the endoscopically active group.SII, NLR, and PLR values were significantly higher in the active UC group, and PNI values exhibited a lower mean than inactive UC patients (p<0.05 for all parameters).In addition, the NLR, PLR, and SII were positively, and PNI was negatively correlated with the endoscopic activity index (respectively, R=0.29, R=0.24, R=0.38, R=-0.32; and for all parameters, p<0.001).Conclusion: PNI and SII were significantly associated with UC activity.PNI and SII may be useful tools for assessing disease activity in UC.