A systematic review of epidemiological studies on the association between organophosphate flame retardants and neurotoxicity

Review question / Objective: This study aims to collect published or unpublished related studies systematically and comprehensively, and screen out the articles that meets the quality standards for qualitative combination, so as to draw a relatively reliable comprehensive conclusion on the relationship of organophosphate flame retardants (OPFRs) with neurodevelopmental toxicity. Eligibility criteria: In brief, epidemiological studies including cohort study, case-control study and cross-sectional survey were screened. Studies regarding relationships between human exposure to organophosphate esters and neurotoxicity were possible eligible for the present systematic review. The adverse neurodevelopmental outcomes included development of cognition, behavior, motor, brain change, emotion, etc. Studies that did not meet the above criteria were not included in this systematic review.