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Toxoplasma gondii Infection Decreases Intestinal 5-Lipoxygenase Expression, while Exogenous LTB4Controls Parasite Growth

Ester Cristina Borges Araujo,Marisol Patricia Pallete Briceño,Yusmaris Cariaco,Mário Cézar Oliveira,Marcos Paulo Oliveira Almeida,Natália Carnevalli de Miranda,Neide Maria Silva

Infection and Immunity（2022）

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Abstract
5-Lipoxygenase (5-LO) is an enzyme required for the production of leukotrienes and lipoxins and interferes with parasitic infections.In vitro,Toxoplasma gondiiinhibits leukotriene B4(LTB4) production, and mice deficient in 5-LO are highly susceptible to infection. The aim of this study was to investigate the effects of the pharmacological inhibition of the 5-LO pathway and exogenous LTB4supplementation during experimental toxoplasmosis.
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