Molecular Characterization of Oropharyngeal Squamous Cell Carcinoma (OPSCC) Surgical Margin

Kors Abou Tsima,Ezić Jasmin,Ammerpohl Ole,Benckendorff Julian, Barth F.E. Thomas,Bens Martin,Thomas Jaya,Kraus M. Johann,Doescher Johannes, von Witzleben Adrian,Theodoraki Marie-Nicole,Brunner Cornelia,Greve Jens,Schuler Patrick,Hoffmann K. Thomas,Ottensmeier Christian,Kestler A. Hans,Laban Simon

Laryngo-rhino-otologie（2022）

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摘要

Introduction Up to 30% of OPSCC patients experience locoregional recurrence following curative surgery with adjuvant treatment. Surgical margins are assessed pathohistologically, but molecular changes predate microscopic detection of dysplasia. We aim to establish molecular signatures discriminating tumors (TU) from their respective clear resection margins (RM) & healthy mucosa (HM).

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关键词

oropharyngeal squamous cell carcinoma,squamous cell carcinoma,opscc

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