Hedgehog signaling pathways in multiple myeloma

I. Dulcamare,S. Giallongo,N. Vicario,G. Scandura,A. Barbato,E. La Spina,L. Longhitano,D. Cambria,D. Tibullo,T. Zuppelli, D. Lo Furno,R. Parenti,G. Li Volti,G.A. Palumbo,F. Di Raimondo, A. Romano,C. Giallongo

Annals of research in oncology（2022）

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Abstract

Multiple myeloma (MM) is a hematological disease characterized by the uncontrolled proliferation of bone marrow malignant plasma cells. Localization and survival of malignant cells relies on bone marrow niche, in turn determined by the interaction between MM cells and mesenchymal stromal cells (MSCs). Several reports suggest that Hedgehog (Hh) pathway plays an outstanding role … Continued

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Key words

Hedgehog Signaling,Bone Marrow Microenvironment

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