The role of immunohistochemistry in the diagnosis and clasification of gastrointestinal lymphoma

Gastrointestinal lymphoma has a better prognosis than primary adenocarcinoma and responds well to chemotherapy if diagnosed correctly and promptly. WHO classification (2016) for this heterogeneous group of diseases has emphasized the role of immunohistochemistry and molecular biology. Determining the origin of tumor cells as B-lymphocytes or T-lymphocytes, in the marginal zone, mantle zone, or germinal center regions by identifying specific immune phenotypes by immunohistochemical techniques is an advanced method. Thereby helping to identify most types of gastrointestinal lymphoma, helping to orient targeted treatment, and contributing to improving prognosis as well as improving quality of life for patients. The role of molecular biology in the classification and prognosis of subtypes of gastrointestinal lymphoma is still studying. Key words: Gastrointestinal lymphoma classification, Immunohistochemistry, Review