Directing Multicellular Organization by Varying the Aspect Ratio of Soft Hydrogel Microwells (Adv. Sci. 17/2022)

Directing Multicellular Organization In article number 2104649, Lewis H. Romer, David H. Gracias, and co-workers report the discovery of an endothelial cell self-organization mechanism that is guided simply by tuning the aspect ratio of 3D geometry on soft hydrogel substrates. This mechanism is driven by a balance between intra- and extracellular interactions and is independent of protein or chemical patterning.