Hsa_circ_0084904 drives cervical cancer advancement by modulating the miR- 578/AURAK pathway

Abstract Cervical cancer (CC) is associated with elevated prevalent rates. Circular RNAs (circRNAs) play vital functions in the pathogenesis of various cancers, such as CC. Here, we evaluated the function and associated molecular mechanisms of hsa_circ_0084904 (circKIAA1429) in CC progression. Analysis of dataset GSE102686 showed that hsa_circ_0084904 expressions were elevated. Function assays found that hsa_circ_0084904 knockdown repressed cell proliferation, formation of colonies, as well as invasion capacities in vitro. In vivo, it reduced tumor progression. Furthermore, in CC cells, hsa_circ_0084904 was shown to upregulate AURKA by sponging miR-578. MiR-578 silencing or AURKA overexpression reversed the effects associated with hsa_circ_0084904 silencing. In conclusion, hsa_circ_0084904 is a potential regulator of CC tumorigenesis via modulation of miR-578/AURKA axis and highlight a therapeutic potential for hsa_circ_0084904 against CC.