The Impact of Gender Identity Stigma and Mental Health on HIV Treatment Among Transgender Women in Argentina

In Argentina, HIV prevalence in transgender women (TGW) is high while engagement in HIV treatment is low due to multiple factors: gender identity stigma (GIS), mental health problems (e.g., depressive symptoms) and substance use. This study examined the impact of these factors on HIV treatment uptake among TGW in Argentina. A sample of 79 TGW “on” and “off” treatment completed questionnaires to assess GIS, depressive symptoms (CES-D), alcohol (AUDIT) and drug use (DAST-10), suicidal ideation, HIV-related stigma (HIV Stigma Scale) and support from family. From them, 36.7% met criteria for “off” HIV treatment; 49.4%, for significant depressive symptoms; 53.2%, for hazardous alcohol use; and 29.7%, for problems related to drug use. GIS was positively associated with depressive symptoms and HIV-related stigma, both in TGW “on” and “off” treatment, and with alcohol and drug use, only in the last group. In the multivariable model, only experiences of GIS from the police were negatively associated with being “on” treatment, whereas GIS in workplaces (excluding sex work venues) were associated with increased odds of being “on” treatment. GIS, specifically from the police, has a far-reaching impact on the physical and emotional health of TGW living with HIV in Argentina, as it is associated with negative mental health indicators, substance use and suboptimal HIV care uptake.