AB0755 Hip denervation and intra-articular hydration in axial spondyloarthritis patients with hip damage

BackgroundThe hip joint is frequently affected in axial spondyloarhritis (SpA) of the adults with destructive effect in untreated patients. About 35% of axial SpA patients had either unilateral or bilateral hip arthritis. Destruction is more common with early-onset, active disease, or enthesitis [1, 2].ObjectivesThe aim of this study is to evaluate the effect of hip denervation (HD) and intra-articular hydration (IAH) on pain, function score, hip mobility scores in a cohort of axial SpA patients with grade 3 and 4 hip BASRI score.MethodsWe enrolled 40 patients who fulfilled ASAS criteria for axial SpA. All had hip involvement with grade 3 or 4 BASRI score at baseline.They were divided into 4 groups; group one received placebo, group 2 HD, group 3 IAH, and group 4 received HD and IAH. They all were assessed at baseline and after 4 weeks and 12 weeks. Outcome measures included; VAS, semi-quantitative scores of tenderness for the hip, range of motion, and Harris functional hip score (HHS).ResultsA significant improvement of VAS pain, tenderness score, ROM, HHS were detected in group 4 versus other groups (p < 0.05). Group 2 had significantly lower scores of tenderness and pain compared to group 3 (p < 0.05). In contrast, the patients of group 3 show better ROM and HHS than the patients of group 2 (p < 0.05). At 4- and 12-week, all therapeutic groups (2, 3, and 4) show considerable improvement in comparison to placebo (group 1) (p < 0.05).ConclusionHD and IAH can improve pain and function in damaged hip of axial SpA patients, especially when concurrently used.References[1]Han, Q., et al., A Comprehensive Assessment of Hip Damage in Ankylosing Spondylitis, Especially Early Features. Frontiers in Immunology, 2021. 12: p. 880.[2]Elsaman, A., A. Hamed, and A. Radwan, Ultrasound-guided epidural block in axial spondyloarthritis patients with limited spine mobility: a randomized controlled trial. The Korean journal of pain, 2021. 34(1): p. 114.Disclosure of InterestsNone declared