Serum sulfonylurea receptor-1 is correlation to perihematomal edema after intracerebral hemorrhage and as a biomarker of clinical prognosis in patients with intracerebral hemorrhage

Abstract Background Sulfonylurea receptor-1(Sur1) and transient receptor potential melastatin 4(Trpm4) are implicated in acute brain injury. We determine whether serum Sur1 and Trpm4 concentrations are associated with spontaneous intracerebral hemorrhage(ICH) related perihematomal edema(PHE) and clinical outcome after ICH. Methods Serum Sur1 and Trpm4 concentrations were measured in 51 healthy controls and 51 patients with ICH. modified Rankin Scale (mRS) score and non-contrast computed tomography (NCCT) were recorded to assess perihematomal edema (PHE) severity. Modified Rankin Scale(mRS) score of 4–6 at 3 months after ICH was defined as an unfavorable outcome. Results Serum Sur1 and Trpm4 concentrations were substantially higher in patients with ICH than in controls. Peak PHE volume was positively correlated with baseline Sur1(r = 0.302, p = 0.031) and more significant related to peak Sur1(0.346, 0.013). Under receiver operating characteristic curve, peak Sur1 levels remained as an independent predictor of poor outcome (OR1.574, 95% CI, 1.144 to 2.165). Conclusions Elevated serum Sur1 levels are related to PHE severity and are independently associated with poor prognosis after ICH, indicating that serum Sur1 may have the potential to be a prognostic biomarker of ICH.