The Immunomodulating properties of TAHITIAN NONI® Juice

The immunomodulating properties of Morinda citrifolia (noni) fruit and TAHITIAN NONI® Juice as demonstrated in human clinical trials and in vivo are reviewed. The ability of noni juice to influence the function of the immune system has been demonstrated in both human and animal studies. Such effects have been seen with as little as 0.8 ml/kg via the oral route. The results from the several human and animal studies agree very well. Increased natural killer cell activity is a likely a major contributor to the improved outcome and survival described in the case report, as well as seen in LLC and S180 tumor bearing mice. Increased IFN-γ production is also an important mechanisms of action through which noni improves immune function. IFN-γ promotes natural killer cell activity and macrophage lysosomal activity (a function of phagocytosis), activities both seen in the human and bovine studies. Further, the effect of noni juice on the human immune system is supported by evidence of its antioxidant action in humans.