Synthesis and in vitro anticancer evaluation of novel flavonoid-based amide derivatives as regulators of the PI3K/AKT signal pathway for TNBC treatment

Dailong Zha,Yuanzhi Li,Yingqi Luo, Yingfan Liu, Zehong Lin, Chujie Lin, Siyue Chen,Jiangping Wu,Lihong Yu,Shaobin Chen,Peiquan Zhang,Wenhao Wu,Chao Zhang

RSC Medicinal Chemistry（2022）

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Abstract

Flavonoid-based amide 7t possesses excellent cytotoxicity against MDA-MB-231 cells and its antitumor activity is achieved by affecting the PI3K/AKT pathway with inducing apoptosis.

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