A comprehensive appraisal of meta-analyses in exercise-based stroke rehabilitation with trial sequential analysis

Review question / Objective: This study aims to use the trial sequential analysis (TSA) method to examine if the published meta-analyses concerning stroke rehabilitation reached the required information size and if the overall effect size is robust as well. Condition being studied: Stroke rehabilitation. Eligibility criteria: Studies were included if they 1) were meta-analyses of random control trials (RCTs) on people with stroke, 2) included meta-analyses results in gait speed (or 6MWT) or bal-ance performance. Studies were excluded if they 1) were conference abstracts, letters to the editor 2) lack the statistical parameters such as mean, standard deviations (SD), and number value in the articles and raw data from the cited studies cannot be found.