The RNA Binding Protein HuR Promotes Neuronal Apoptosis in Rats with Spinal Cord Injury via the HDAC1/RAD21 Axis

Changsheng Wang,Xiaobo Zhang,Xitian Zhu,Rongsheng Chen,Nancheng Lian

Neuroscience（2023）

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Abstract

•Silencing HuR relieved rat SCI and inhibited neuronal apoptosis.•Overexpression of RAD21 mitigated SCI and repressed neuronal apoptosis in rats.•Upregulation of HuR elevated HDAC1, reduced RAD21, and promoted neuronal-like apoptosis.•Inhibition of HDAC1 relieved SCI and repressed neuronal apoptosis by promoting RAD21.•HuR deficiency alleviated SCI and inhibited neuronal apoptosis via HDAC1/RAD21.

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Key words

spinal cord injury,HuR,HDAC1,RAD21,neuronal apoptosis

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