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Sensitivity of Hypocretin System to Chronic Alcohol Exposure: A Human and Animal Study

Ronald McGregor,Alessandra Matzeu,Thomas C. Thannickal,Frank Wu,Marcia Cornford,Rémi Martin-Fardon,Jerome M. Siegel

Neuroscience（2023）

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Abstract
•Fewer hypocretin neurons are found in humans with alcohol use disorder.•Smaller size of hypocretin, MCH neurons and activation of microglia was detected.•No changes were observed in the histamine cell group in this same human population.•Rats exposed to alcohol do not show changes hypocretin, MCH or microglia.•Factors secondary to AUD might be responsible for the changes in humans.
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Key words
hypocretin, melanin concentrating hormone, histamine human, alcohol, microglia
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