The 8p12 myeloproliferative disorder. t(8;19)(p12;q13.3): a novel translocation involving the FGFR1 gene

Francine Mugneret,Max Chaffanet,Marc Maynadié,Géraldine Guasch,Bernardine Favre,Olivier Casasnovas,Daniel Birnbaum,Marie‐Josèphe Pébusque

British Journal of Haematology（2000）

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Abstract

Translocations affecting the chromosomal locus 8p12 are hallmarks of an atypical stem cell myeloproliferative disorder. These events disrupt the fibroblast growth factor receptor 1 (FGFR1) gene and fuse the FGFR1 C‐terminus catalytic domain with unrelated proteins. Here, we report on the characterization of the 19q13.3 locus as the fifth FGFR1 chromosomal partner.

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