Immediate early response 3 gene promotes aggressive progression and autophagy of AML by negatively regulating AKT/mTOR.

Yimin Chen,Zhenqian Huang,Shuyi Chen,Li Tan,Lang He,Danyun Yuan,Lixia Zheng, Jing Hua Zhong,Anqiao Li,Heng Zhang,Huo Tan,Lihua Xu

Translational Oncology（2023）

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摘要

IER3 could promote the development of AML and induce autophagy of AML cells by negatively regulating the phosphorylation and activation of AKT/mTOR. By the way, SATB1 may negatively target regulates IER3 transcription.

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关键词

IER3, acute myeloid leukemia, proliferation, autophagy, AKT, mTOR

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