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3D Bioprinted Neural‐Like Tissue as a Platform to Study Neurotropism of Mouse‐Adapted SARS‐CoV‐2 (Adv. Biology 8/2022)

Bruna A. G. de Melo,Mayara V. Mundim,Robertha M. R. Lemes,Elisa M. Cruz,Tais N. Ribeiro,Carolina F. Santiago,Jéssica H. L. da Fonsêca,Julia C. Benincasa,Roberta S. Stilhano,Nathalia Mantovani,Luiz C. Santana,Ricardo Durães‐Carvalho,Ricardo S. Diaz,Luiz M. R. Janini,Juliana T. Maricato,Marimelia A. Porcionatto

Advanced Biology（2022）

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Abstract
Bioprinted Neural-Like Tissue In article 2200002, Maricato, Porcionatto, and co-workers use 3D bioprinting technology for the biofabrication of neural-like tissues composed of natural polymers and murine astrocytes and neurons. The mimetic neural tissue is infected with mouse-adapted SARS-CoV-2, showing permissiveness and specificity with the adapted virus, representing a proof-of-a-concept platform for modeling neuroinfection, contributing to the speed of antiviral drug screening.
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neurotropism,sars‐cov‐2,tissue,mouse‐adapted
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