Evaluation of Autism Spectrum Disorder Risk in Infants with Intraventricular Hemorrhage

Abstract Objective: To evaluate the ASD risk in infants with intraventricular hemorrhage (IVH) using the Modified Checklist for Autism in Toddlers-Revised with Follow Up (M-CHAT-R/F). Study Design: Retrospective cohort study. Infants with IVH admitted to the Baylor Scott & White Health NICU from January 2014 through June 2020. M-CHAT-R/F questionnaire results for ASD risk assessment was used, in addition to the cranial ultrasound findings at NICU discharge.Results: M-CHAT-R/F screening results were found in 165 infants, 80 children had IVH and 85 children had no IVH, 35 infants failed (ASD Risk) and 130 infants passed the M-CHAT-R/F (No-ASD risk). Median birth weight and gestational age were significantly lower in ASD risk group. ASD risk and cerebral palsy were significantly associated with severe IVH. Based on discharge cranial ultrasound findings, ASD risk of infants with resolved IVH was comparable to No-IVH group. Conclusions: The ASD risk increases with lower gestational age, lower birth weight and severe IVH.