The association between concomitant rheumatoid arthritis and peripheral arterial and health-related quality of life and functional capacity: a systematic review

Abstract Background Patients with rheumatoid arthritis (RA) are at an increased risk of cardiovascular disease and vascular morbidity. The association between peripheral arterial disease (PAD) and RA has not been previously investigated within the scope of a review. Conjoined disease manifestations may impact patient well-being, perpetuating increased mortality and quality of life deficits. Objective To investigate the association between RA and PAD, along with RA and the ankle-brachial pressure index (ABPI). The impact of disease concomitance on health-related quality of life (HRQOL) and functional capacity (FC) was also investigated. Methods Individual study appraisal was completed using the Crowe Critical Appraisal Tool (CCAT). A level of evidence analysis was conducted using the American Society of Plastic Surgeons (ASPS) Evidence Rating Scale for Prognostic/Risk Studies. Data Sources: AMED®, CINAHL®, Health Source: Nursing/Academic Edition, MEDLINE®, AHFS®, Cochrane Library and Google scholar. Results 10 studies produced a CCAT rating of ≥ 30 (75%) and were deemed high quality, while a single study demonstrated a score of 26 (65%) indicating moderate quality. A grade “II” level of evidence was determined for a positive association between RA and PAD. A grade of “I” was assigned to the association between ABPI and RA. The impact of concomitant manifestations on HRQOL and FC did not qualify for a level of evidence analysis. Conclusion The systematic inflammatory nature of RA likely contributes to the increased incidence of PAD within the population. Further investigations are required to ascertain the impact of conjoined disease manifestations on HRQOL and FC.