The role of tight junctions in atopic dermatitis: A systematic review

Review question / Objective: The role of tight junctions in atopic dermatitis. Eligibility criteria: Inclusion criteria: Literature from 2009 to 2022, studies written in english. Exclusion criteria: articles focused in diseases other that atopic dermatitis, articles whose full-text version was not available, articles written in language other than English. Main outcome(s): Exploring the crosstalk between TJs and the immune system, in order to develop topical agents that improve TJs functionality. Publication of new data is possible to change our current knowledge as presented in this review in the future, as this is an emerging field.