Epicardial Adipose Tissue, Pulmonary Veins Anatomy, and the P-wave/PR Interval Ratio in Young Patients with Atrial Fibrillation
Social Science Research Network(2022)
Abstract
BACKGROUND Atrial fibrillation (AF) is uncommon in the youngest population. Epicardial adipose tissue (EAT) volume has been proposed as an independent AF risk factor. OBJECTIVE The aim of this retrospective study was to evaluate the impact of the EAT, the anatomy of the pulmonary veins (PVs), and electrocardiogram (ECG) features in these young patients with AF. METHODS Sixty-two patients divided in 2 groups, one with history of paroxysmal AF treated with ablation and the other, a control group, all younger than 30 years of age, were included. Computed tomography scans were performed in both groups to estimate the PVs anatomy and EAT volume. Twelve-lead ECGs were performed in all patients. Patients underwent follow-up in our outpatient clinic (35.9 +/- 18.3 months). RESULTS In the AF group, the EAT volume around the left atrium was 22.25 +/- 9.3 cm3 compared with 12.61 +/- 3.37 cm3, showing a statistically significance difference (P = .003). Family history resulted to be another significant risk factor (P = .009). During follow-up, 67.7% of the patients treated were still free of events. The anatomy and morphology of the right-sided PVs seemed to play a more consistent role in the patients with AF recurrences (P = .04). The P/PR ratio, a new ECG index, seemed predict AF recurrences after ablation (P = .03). CONCLUSION The abundance of EAT seems related to the risk of developing AF in young patients. The recurrence of AF is about 33% and does not seem related to the EAT volume, but rather to the anatomy of the PVs. A higher P/PR ratio might suggest recurrences.
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Key words
Atrial fibrillation,Epicardial adipose tissue,Computed tomography,Cryoballoon ablation,Young patients,ECG AF predictor index
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