High Resolution and Spatiotemporal Place-Based Computable Exposures at Scale.

Place-based exposures, termed "geomarkers", are powerful determinants of health but are often understudied because of a lack of open data and integration tools. Existing DeGAUSS (Decentralized Geomarker Assessment for Multisite Studies) software has been successfully implemented in multi-site studies, ensuring reproducibility and protection of health information. However, DeGAUSS relies on transporting geomarker data, which is not feasible for high-resolution spatiotemporal data too large to store locally or download over the internet. We expanded the DeGAUSS framework for high-resolution spatiotemporal geomarkers. Our approach stores data subsets based on coarsened location and year in an online repository, and appropriate subsets are downloaded to complete exposure assessment locally using exact date and location. We created and validated two free and open-source DeGAUSS containers for estimation of high-resolution, daily ambient air pollutant exposures, transforming published exposure assessment models into computable exposures for geomarker assessment at scale.