Biobank case example: Marshfield clinic

The Personalized Medicine Research Project (PMRP) is a population-based biobank with more than 20,00 participants and DNA, plasma, and serum samples linked to electronic health records. The PMRP research team was one of the first in the United States to develop a population-based study to facilitate genomic discoveries with the long-term aim of delivery of precision medicine in a clinical setting. Genomic data sharing was essential to the success of the project. Rarer conditions required combining data with investigators from other sites to increase sample size, and external collaboration was necessary for the validation of genomic discoveries. Stakeholder engagement throughout the study provided feedback to develop processes to allow genomic data sharing.