Association of GLUT2 and TAS1R2 polymorphisms with dental caries susceptibility in children: a meta-analysis

Abstract Background: This meta-analysis evaluated the association of sweet taste 1 receptor 2 (TAS1R2) and glucose transporter 2 (GLUT2) polymorphisms with dental caries susceptibility in children. Methods: We searched the PubMed, Web of Science, Embase and Cochrane Library databases to retrieve articles published up to 14th December 2022. Stata/SE 17.0 (TX 77845 USA) software was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs). The cohort study, case-control study focusing on the TAS1R2 and GLUT2 polymorphism and dental caries in children were retrieved. The data included basic information of each study and the genotypes and allele frequencies. Results: Three studies were finally included, including 233 cases and 319 controls for rs35874116 in TAS1R2, 268 cases and 183 controls for rs5400 in GLUT2. Allelic model, homozygote model, recessive model, dominant model, and heterozygous model were established to assess the relationship between these two polymorphisms and dental caries susceptibility in children. The GLUT2 rs5400 was associated with caries in Allelic model (A vs. G), Recessive model (AA vs. AG+GG) and Homozygote model (AA vs.GG). The TAS1R2 rs35874116 was associated with caries in Dominant model (CC+CT vs. TT). The outcome from GLUT2 rs5400 and TAS1R2 rs35874116 were not stable in the sensitivity analysis. Conclusions: The results of this meta-analysis showed that the Allelic model, Recessive model and Homozygote model of the GLUT2 rs5400 and the Dominant model of TAS1R2 rs35874116 were associated with an increased risk of caries in the case group compared with the control group. But the outcome from TAS1R2 rs35874116 was not stable. PROSPERO registration number: CRD42022379301