Lactate levels and CD3+ T cells indicate how well patients with sepsis would respond to treatment: a single-center retrospective analysis

Abstract Background and aims Sepsis is one of the most common causes of death in intensive care units. Numerous studies have been performed on lymphocyte immunity in sepsis patients, but they seldom pay attention to whether lactate levels and T lymphocytes affect sepsis immunity. This study focused on how well lactate levels and CD3+ T cells will influence the outcome of sepsis patients. Methods This is a single-center retrospective investigation. All of the participants satisfied the diagnostic standards for sepsis 3.0. We collected the results of the lymphocyte subset within 24 hours of admission to ICU as well as the first lactate levels and other medical indicators.Followed up the patients for 28 days, we separated the participants into survival and mortality groups and then we processed uni-variate and multivariate analyses. Results A total of 132 sepsis patients who were older than 18 years old and met the diagnostic standards for sepsis 3.0 were included. Only 107 patients, including 53 in the survival group and 54 in the mortality group, were enrolled into statistical analysis. Based on uni-variate and multivariate analysis results, lactate levels and the quantity of CD3+ T cells were independent predictive markers that affected 28-day mortality in sepsis patients. ConclusionInitial lactate levels at ICU admission may predict outcomes in sepsis patients, and CD3+ T-lymphocyte will influence how well a patient will respond to treatment. Patients with elevated lactate levels and overall lower CD3+ T-cell counts at ICU admission should receive greater care and powerful medication. Trial registration：retrospectively registered