The association between red blood cell distribution width, C-reactive protein and renal function in patients with type2 diabetes mellitus

Abstract Objective Red cell distribution width (RDW) and C-reactive protein (CRP) were respectively considered as important biomarker of cardiovascular diseases and inflammatory diseases.We aimed to evaluate the association of RDW) ,CRP with renal function in patients with type2 diabetes mellitus(T2DM ). Methods Patients with T2DM with a wide range of estimated glomerular filtration rate(eGFR) and proteinuria from 2019 to 2021 at Henan Provincial People’s Hospital were included in this study.. Blood samples from T2DM patients with normal eGFR(n = 146) and T2DM patients with decreased eGFR(n = 246) were collected. Clinical characteristics, routine blood test results and biochemical parameters were recorded, including age, gender, red blood cell, hemoglobin, RDW, platelet, CRP, albumin, total bilirubin, glucose, high-density lipoprotein, uric acid, creatinine, urea nitrogen and cystatin C. The effect of RDW and CRP level on the renal function was evaluated by using multiple linear step.wise regression analysis. Results Compared with the T2DM patients with normal eGFR,the the T2DM patients in decreased eGFR group had lower levels of hemoglobin, albumin and platelet, and higher levels of CRP, Uric acid, creatinine and cysC. Moreover, the levels of RDW levels were negatively correlated with eGFR (r=-0.224,p < 0.001), but positively related with CRP (r = 0.211,p < 0.001). Importantly, Multiple linear regression analysis showed that the levels of RDW had significant effects on decline of renal function (β = 0.091, p = 0.002). Conclusions RDW were an independent risk factor for for decline in renal function in patients with T2DM, RDW was also positively correlated with CRP.