Visible-light promoted N-aminoalkylation of quinazolinones

A visible-light promoted direct coupling of quinazolinones and simple alkylamides to approach highly functionalized N-aminoalkyl quinazolinones was reported. This protocol serves as a highly efficient and straightforward strategy for N-aminoalkylation transformation of quinazolinones employing tert-Butyl peroxybenzoate as an oxidant in combination with visible-light irradiation conditions. This process features mild reaction conditions and tolerance for a wide range of functional groups. Synthetically important and highly functionalized N-aminoalkyl quinazolinones were afforded high levels of yields (up to 86% yield).