LBODP044 Effects Of Dietary Supplementation On Progression To Type 2 Diabetes Single Center Randomized Double-blind Placebo-controlled Trial An Interim Analysis At 24 Weeks
Journal of the Endocrine Society(2022)
摘要
Abstract Objectives To examine the effect of dietary supplements on diabetic risk, blood glucose level and lipid profiles. Methods A randomized, double-blinded, placebo-controlled study was conducted at Rajavithi Hospital. Participants with prediabetes were randomly allocated to three arms of dietary supplements: placebo (PL) or curcumin plus fish oil and vitamin D (CFD), or curcumin plus fish oil (CF) for 24 weeks. Primary outcomes of the trial were progression to overt diabetes and glycemic indices (fasting plasma glucose, 75-g OGTT 2-h plasma glucose or HbA1C). Secondary outcomes were body weight change, BMI and lipid profiles. Results A total of forty-seven participants (PL, n = 16; CFD, n = 15; CF, n = 16) were included in the study. At 24 weeks, the intervention groups significantly lowered the progression of type 2 diabetes among prediabetes individuals, the interventions groups -0.77 ± 1.17, and 0.19 ± 1.28, the placebo group 0.64 ± 1.82, P value = 0. 046 (P<0. 05). However, the results failed to demonstrate the effect of dietary supplements on weight, BMI and blood chemistries. Conclusion The combined dietary supplements which contained curcumin-fish oil-vitamin D, lowered the risk of prediabetes progression to overt diabetes at six months follow up and well-tolerated among the participants. Keywords: dietary supplements, curcumin, fish oil, vitamin d, prediabetes Presentation: No date and time listed
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关键词
dietary supplementation,diabetes single center,double-blind,placebo-controlled
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