Role of Biosensors in Regenerative Therapeutics: Past, Present, and Future Prospects

Regenerative medicine is an integrative strategy that involves technology and basic sciences to stimulate regeneration in damaged and wounded tissues and organs. A variety of regenerative medicine therapies, such as those for wound healing and orthopedics, have been approved by the Food and Drug Administration (FDA) and are also now commercially available. The existing therapy of transplanting entire organs and tissues to heal defects and loss is hampered by a scarcity of donors and subsequent immunological problems. However, these issues could be overcome with the introduction of regenerative medicine technologies. Biosensors serve as a program interface for those technologies, allowing for real-time monitoring of system behavior for improved efficiency. Biosensors with increased sensitivity and performance have been developed anchor advancements in controlled therapies. The advent of noninvasive technologies to assess differentiation state in stem cell-based therapies is highly coveted and could be extremely beneficial. Different biosensing techniques are available for sensing different molecules. In this chapter, we will briefly discuss about regenerative therapeutics and its recent advancement in personalized medicine. Furthermore, discussion is included on different microfabrication and nanofabrication technologies that have opened a new paradigm in the field of biosensors as a potential form of technology to speed up development in various aspects of regenerative medicine.