Mineral density and processes of bone tissue remodeling in child population living in iodine-deficient biogeochemical territory

The territory of the Republic of Bashkortostan belongs to the regions with natural iodine deficiency in soil and water. The population of the republic is at risk of developing iodine deficiency conditions. The aim of the study was to evaluate the frequency of a decrease in bone mineral density and the level of markers of osteoresorption and bone formation in young schoolchildren and adolescents living in a region with natural iodine deficiency. Materials and methods. The survey covered 288 students of general education schools aged 11–12 and 309 students aged 14–15. Theauthors studiedconcentration of iodine in urine, plasma levels of thyroid hormones (thyroid stimulating hormone, free thyroxine), levels of calcium, magnesium, phosphorus, C-terminal telopeptides of type I collagen, activity of the bone isoenzyme of alkaline phosphatase. The volume of the thyroid gland, the mineral density of the bone tissue of the middle diaphysis of the tibia, the lower third of the radius were determined by ultrasonometry. Results and discussion. It was found that children have a high prevalence of iodine deficiency from 44% to 57.6% and a decrease in the concentration of iodine in the urine, an increase in the content of thyrotropin, calcium and magnesium in the blood plasma. Insufficient iodine supply leads to a slowdown in the intensity and imbalance of remodeling with a decrease in bone formation processes.