Treatment with the Soluble Guanylate Cyclase Activator BAY 60-2770 Restores in Vitro Bladder Contractile Responses in a Rat Model of Chronic Prostatitis

Ozgu Aydogdu,Fernando Perez, Jan Rataj, Felicia Nilsson,Patrik Aronsson,Thomas Carlsson,Peter Sandner,Bhavik Patel,Gunnar Tobin,Michael Winder

Continence（2022）

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摘要

•Induction of chronic prostatitis led to attenuation of purinergic bladder contractions.•Expression of functional bladder contractile receptors was unaltered.•Treatment with a soluble guanylate cyclase activator restored purinergic function.

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关键词

sGC activator,Chronic prostatitis,Urinary bladder,Organ bath,In vitro,Animal model

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