The application of RNA sequencing in precision cancer medicine
Reference Module in Biomedical Sciences(2024)
Abstract
Advances in next-generation sequencing (NGS) technologies enabling comprehensive genomic and transcriptomic profiling has enabled researchers to make significant strides toward precision medicine approach to diagnosis and treatment of cancers. Indeed, large-scale tumor profiling has become a routine aspect in clinical decision-making. This chapter details the application of RNA sequencing (RNA-seq) in various aspects of precision oncology including, biomarker discovery, characterization of tumor heterogeneity, resistance, the tumor's microenvironment and immunotherapy, and cancer neoantigens.
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Key words
rna,cancer
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