Abstract TP2: Iv-thrombolysis Improves Perfusion Profiles In Patients With Anterior Circulation Occlusion Regardless Of Recanalization

Introduction: Recent publications suggest a positive added effect of iv-thrombolysis (IVT) in patients that undergo endovascular treatment (EVT). It is hypothesized that thrombolytics might have a beneficial impact on microcirculation beyond recanalization. We aim to analyze the potential impact of IVT in patients who underwent a repeated CTP after interhospital transfer. Methods: We retrospectively screened 116 patients transferred to our comprehensive stroke center from a primary stroke center capable to perform CTP from June 2021 to August 2022. We collected clinical and radiological data of patients that underwent CTP at both centers, which were analyzed with Rapid software. A neurointerventionalist assessed the occlusion location in CTA. Results: Twenty-eight patients with anterior circulation occlusion underwent two multimodal studies, median time between CTPs was 168[142-190]min. Fifteen (53.6%) patients received IVT in the primary stroke center and 13(46.4%) received EVT. Reperfusion occurred in 3(10.7%) cases, migration to distal segments in 5(17.9%). Among the 20 patients without changes in the occlusion location, CTP volumes remained stable (Tmax>6s 61[41-141]ml vs 62[24-178], p=0.72; Tmax>10s 19[8-96] vs 13[0-105], p=0.55; CBF30 0[0-66] vs 0[0-65], p=0.99). CTP volumes tended to decrease with IVT, but a modest increase was observed in patients that did not receive IVT (Tmax>6s -17[-29,+8]ml vs +22[-8,+42], p=0.08; Tmax>10s -8[-16,+6] vs +6[0,+37], p=0.10; CBF<30% 0[-6,0] vs 0[0,+4], p=0.14) (figure). In a linear regression to predict CTP volumes in the second center, interaction between baseline values and IVT was significant for Tmax>10s (p=0.06) and CBF<30% (p<0.05). Conclusion: In acute stroke patients with a LVO, no substantial changes are expected in CTP volumes in the absence of recanalization. However, patients that receive IVT tend to present reduced hypoperfusion volumes as compared with patients that do not receive IVT.