In vivo and ex vivo have long-term durability in antibiotic-associated drug reaction with eosinophilia and systemic symptoms

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a presumed T cell-mediated drug hypersensitivities. The durability of T-cell immune responses to implicated drug over extended periods of time as well as in vivo (e.g. intradermal skin testing [IDT]) and ex vivo (e.g. Enzyme linked ImmunoSpot [ELISPOT] assay) tests remain ill defined. We sought to examine the durability of immunological responses over time in a cohort of antibiotic-associated DRESS.